New Step by Step Map For ceesdekker
New Step by Step Map For ceesdekker
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‘Sure, that may be about proper. I try to find a physical comprehension of Organic methods in a very base-up way. I do think you may distinguish a few strains of analysis in my team for the time being. The 1st concerns chromosome construction: How will you receive a metre-lengthy DNA polymer folded and organised in this type of microscopic mobile? Now we have created visualisation tactics that allow us to study how, by way of example, SMC proteins loop DNA (online video on Youtube) in order to Develop up chromosomes.
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, Groningen researchers present the outcome in their initiatives to make labs a lot more sustainable and provide techniques for other labs.
2007, initial authentic-time detection of strand Trade in homologous recombination by RecA; discovery of a lower persistence duration of ends of microtubules; and settled the system of biosensing with carbon nanotubes
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and 1st ever review from the dynamics DNA supercoils and the invention of supercoil hopping
Experimental stage diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is always that these components alongside one another make up a residing system. The key of reported daily life, I do think, lies while in the interactions, the interaction of Individuals molecules. The massive issue with regard to the origin of existence remains unanswered. How did we ever evolve from basic molecules into the really elaborate units we see right now? We do not know. I want to work on These types of large, open issues.’
Move-driven rotary motors including windmills and drinking water wheels push functional processes in human society. Despite the fact that samples of these types of rotary motors also feature prominently in cell biology, their synthetic building on the nanoscale has remained hard. In this article we reveal flow-driven rotary motion of a self-organized DNA nanostructure that's docked onto a nanopore in a thin strong-state membrane. An elastic DNA bundle self-assembles into a chiral conformation on phoretic docking on to the good-condition nanopore, and subsequently displays a sustained unidirectional rotary motion of up to 20 rev s−1.
2003, shown the main biosensors built away from a carbon nanotube; settled the construction and system of DNA maintenance proteins; and discovery of a different strategy for fabricating sound-state nanopores https://www.ceesdekker.net for DNA translocation
It had been all through this era that Dekker carried out research on magnetic spin techniques and on sound in superconductors and semiconductors.
An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes
‘That worries the synthetic cell, as Component of the Dutch BaSyC initiative. Craig Venter looked prime-down in those days and determined about 5 hundred genes which can be minimally demanded to get a operating mobile. We wish to search base-up: how can we move from a several molecules to an entire biological technique?
Visualization of unstained DNA nanostructures with Superior in-emphasis transmission electron microscopy approaches
Solid-state nanopores have proven to be a remarkably flexible probe for single-molecule Evaluation of DNA. I will describe some of our recent conclusions – precisely DNA knots – as well as our endeavours to extend the abilities of stable-condition nanopores even even more, inside the route of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.